human herpesvirus-6 dna and langerhans cell histiocytosis
نویسندگان
چکیده
conclusions our study is the first to investigate patients with lch and its possible association with hhv-6 in iran. considering the p level of 0.11, which is statistically insignificant, our findings fail to support the hypothesis of a possible role for hhv-6 in the pathogenesis of lch. these results are in concordance with previous investigations showing negative results. results there was no significant difference in the prevalence of hhv-6 detection between the lch patients and the control subjects. hhv-6 was found by nested pcr in one (2.1%) of the 48 lch patients and in six (12.5%) of the 48 control cases. p = 0.11 was calculated using fisher’s exact test (or: 0.15; 95%ci: 0.02 - 1.29). methods in this retrospective study, we investigated the presence of hhv-6 dna in 48 patients with lch, using paraffin-embedded tissue samples, and in 48 controls (age- and tissue-matched) using the nested polymerase chain reaction (nested pcr) method. the patients had been treated at the department of pediatric pathology from 2002 - 2013 and had undergone operations for reasons other than infectious disease. only the pathology reports were retrospectively reviewed, and the patients were anonymous. objectives hhv-6 infections are reported to be associated with lch, but no such reports could be found on iranian children in the english-language medical literature. this study investigated the presence of hhv-6 in iranian children with lch. background langerhans cell histiocytosis (lch) is a rare histiocytic proliferative disorder of unknown etiology that mainly affects young children. the histological feature is the granuloma-like proliferation of langerhans-type dendritic cells. the possible role of viruses such as epstein-barr virus (ebv, hhv-4), human herpesvirus-6 (hhv-6), herpes simplex virus (hsv) types 1 and 2, and cytomegalovirus (cmv, hhv-5) in the pathogenesis of lch has been suggested in some studies; however, this still remains under debate.
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عنوان ژورنال:
archives of pediatric infectious diseasesجلد ۴، شماره ۴، صفحات ۰-۰
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